3. Round | 10/02/2022 | Real Estelí FC | - | Managua FC | 1:2 | ||||
4. Round | 14/02/2022 | Managua FC | - | H&H Export Sébaco | 3:2 | ||||
6. Round | 28/02/2022 | Managua FC | - | UNAN Managua | 3:3 | ||||
8. Round | 07/03/2022 | Real Madriz | - | Managua FC | 1:0 | ||||
9. Round | 11/03/2022 | Managua FC | - | CD Walter Ferretti | 2:1 |