| 31. Round | 15/01/2022 | Grimsby Town | - | Altrincham FC | 2:0 | ||||
| 25. Round | 22/01/2022 | Grimsby Town | - | Bromley FC | 1:2 | ||||
| 27. Round | 29/01/2022 | Grimsby Town | - | Wealdstone FC | 2:1 | ||||
| 28. Round | 05/02/2022 | Notts County | - | Grimsby Town | 1:2 | ||||
| 22. Round | 08/02/2022 | Grimsby Town | - | King's Lynn | 0:0 | ||||
| 29. Round | 12/02/2022 | Grimsby Town | - | Aldershot Town | 3:1 | ||||
| 32. Round | 26/02/2022 | Dover Athletic | - | Grimsby Town | 1:3 | ||||
| 34. Round | 12/03/2022 | Yeovil Town | - | Grimsby Town | 0:2 | ||||
| 35. Round | 19/03/2022 | Boreham Wood | - | Grimsby Town | 0:0 | ||||
| 36. Round | 22/03/2022 | Grimsby Town | - | Solihull Moors | 1:2 | ||||
| 37. Round | 26/03/2022 | Grimsby Town | - | Dagenham & Redbridge | 2:1 | ||||
| 38. Round | 02/04/2022 | Chesterfield FC | - | Grimsby Town | 1:4 | ||||
| 39. Round | 09/04/2022 | Weymouth FC | - | Grimsby Town | 0:0 | ||||
| 40. Round | 15/04/2022 | Grimsby Town | - | Stockport County | 2:1 |  |
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| 41. Round | 18/04/2022 | King's Lynn | - | Grimsby Town | 0:1 | ||||
| 42. Round | 23/04/2022 | Grimsby Town | - | Torquay United | 2:1 | ||||
| 45. Round | 07/05/2022 | Grimsby Town | - | Maidenhead United | 1:3 |
England