| 1. Round | 23/01/2022 | Juventus Managua | - | Managua FC | 1:2 | ||||
| 2. Round | 05/02/2022 | Juventus Managua | - | Diriangén FC | 0:2 | ||||
| 3. Round | 09/02/2022 | Real Madriz | - | Juventus Managua | 0:3 |  |
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| 4. Round | 13/02/2022 | Real Estelí FC | - | Juventus Managua | 2:1 | ||||
| 5. Round | 19/02/2022 | Juventus Managua | - | H&H Export Sébaco | 5:1 | |
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| 6. Round | 28/02/2022 | Club Deportivo Ocotal | - | Juventus Managua | 0:1 | |
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| 7. Round | 04/03/2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | ||||
| 8. Round | 07/03/2022 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 10. Round | 14/03/2022 | Managua FC | - | Juventus Managua | 0:2 | ||||
| 11. Round | 20/03/2022 | Diriangén FC | - | Juventus Managua | 2:2 |  |
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| 12. Round | 03/04/2022 | Juventus Managua | - | Real Madriz | 1:1 | |
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| 13. Round | 07/04/2022 | Juventus Managua | - | Real Estelí FC | 0:3 | ||||
| 14. Round | 09/04/2022 | H&H Export Sébaco | - | Juventus Managua | 2:0 | ||||
| 17. Round | 29/04/2022 | Juventus Managua | - | ART Municipal Jalapa | 2:1 | |
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| 18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 |
Spain