| 2. Round | 26/01/2025 | Isidro Metapán | - | Once Deportivo | 3:1 | ||||
| 3. Round | 31/01/2025 | Municipal Limeño | - | Isidro Metapán | 0:0 |  |
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| 4. Round | 02/02/2025 | Isidro Metapán | - | CD Cacahuatique | 0:0 | ||||
| 5. Round | 09/02/2025 | Platense Zacatecoluca | - | Isidro Metapán | 0:2 | ||||
| 6. Round | 13/02/2025 | Isidro Metapán | - | Dragón | 2:1 | ||||
| 7. Round | 16/02/2025 | FAS | - | Isidro Metapán | 0:0 | ||||
| 9. Round | 26/02/2025 | CD Águila | - | Isidro Metapán | 2:0 | ||||
| 10. Round | 02/03/2025 | Isidro Metapán | - | Alianza | 2:1 | ||||
| 11. Round | 09/03/2025 | Fuerte San Francisco | - | Isidro Metapán | 0:1 | |
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| 13. Round | 23/03/2025 | Once Deportivo | - | Isidro Metapán | 0:2 | ||||
| 15. Round | 29/03/2025 | CD Cacahuatique | - | Isidro Metapán | 0:0 | ||||
| 16. Round | 06/04/2025 | Isidro Metapán | - | Platense Zacatecoluca | 2:1 | ||||
| 17. Round | 09/04/2025 | Dragón | - | Isidro Metapán | 2:3 | ||||
| 18. Round | 13/04/2025 | Isidro Metapán | - | FAS | 3:1 |  |
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| 19. Round | 20/04/2025 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 20. Round | 24/04/2025 | Isidro Metapán | - | CD Águila | 2:2 | ||||
| 21. Round | 27/04/2025 | Alianza | - | Isidro Metapán | 1:0 | ||||
| 22. Round | 03/05/2025 | Isidro Metapán | - | Fuerte San Francisco | 0:1 |
Ecuador