| 9. Round | 20/11/2021 | Mosta FC | - | Gżira United | 2:2 | ||||
| 10. Round | 28/11/2021 | Gżira United | - | Gudja United | 3:2 | ||||
| 11. Round | 04/12/2021 | Sirens FC | - | Gżira United | 1:3 |  |
|||
| 12. Round | 12/12/2021 | Hibernians FC | - | Gżira United | 3:1 | ||||
| 13. Round | 18/12/2021 | Gżira United | - | St. Luċija FC | 2:2 | ||||
| 14. Round | 18/01/2022 | Sliema Wanderers | - | Gżira United | 1:3 | ||||
| 15. Round | 23/01/2022 | Gżira United | - | Valletta FC | 1:1 | ||||
| 16. Round | 30/01/2022 | Birkirkara FC | - | Gżira United | 1:0 | ||||
| 17. Round | 05/02/2022 | Gżira United | - | Hamrun Spartans | 4:1 | ||||
| 18. Round | 12/02/2022 | Balzan FC | - | Gżira United | 1:3 | ||||
| 19. Round | 20/02/2022 | Gżira United | - | Floriana FC | 1:2 | ||||
| 20. Round | 27/02/2022 | Gżira United | - | Mosta FC | 3:4 | ||||
| 21. Round | 05/03/2022 | Gudja United | - | Gżira United | 1:2 | ||||
| 22. Round | 12/03/2022 | Gżira United | - | Sirens FC | 2:1 |
Croatia