| 1. Round | 21/02/2021 | Alianza | - | Sporting San Miguelito | 0:0 | ||||
| 3. Round | 07/03/2021 | Tauro FC | - | Sporting San Miguelito | 0:1 | ||||
| 4. Round | 13/03/2021 | Deportivo del Este | - | Sporting San Miguelito | 1:1 | ||||
| 5. Round | 18/03/2021 | Sporting San Miguelito | - | Árabe Unido | 3:2 | ||||
| 6. Round | 21/03/2021 | UD Universitario | - | Sporting San Miguelito | 2:1 | ||||
| 7. Round | 24/03/2021 | Sporting San Miguelito | - | Independiente de La Chorrera | 1:3 |  |
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| 11. Round | 17/04/2021 | Sporting San Miguelito | - | Atlético Chiriquí | 2:1 | ||||
| 12. Round | 21/04/2021 | Sporting San Miguelito | - | Alianza | 0:0 | ||||
| 13. Round | 25/04/2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | ||||
| 15. Round | 06/05/2021 | Sporting San Miguelito | - | Deportivo del Este | 1:0 | ||||
| 16. Round | 08/05/2021 | Árabe Unido | - | Sporting San Miguelito | 1:2 |
Panama