| 2. Round | 25/02/2022 | Cobh Ramblers | - | Wexford FC | 2:3 | ||||
| 15. Round | 06/05/2022 | Cobh Ramblers | - | Galway United | 0:4 |  |
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| 16. Round | 13/05/2022 | Waterford FC | - | Cobh Ramblers | 4:2 | ||||
| 17. Round | 20/05/2022 | Treaty United | - | Cobh Ramblers | 2:2 |  |
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| 19. Round | 10/06/2022 | Athlone Town | - | Cobh Ramblers | 5:2 | ||||
| 21. Round | 24/06/2022 | Cork City | - | Cobh Ramblers | 1:0 |  |
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| 29. Round | 19/08/2022 | Cobh Ramblers | - | Cork City | 1:2 | ||||
| 30. Round | 02/09/2022 | Treaty United | - | Cobh Ramblers | 1:0 | ||||
| 31. Round | 09/09/2022 | Cobh Ramblers | - | Galway United | 1:1 |  |
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| 34. Round | 07/10/2022 | Cobh Ramblers | - | Longford Town | 2:4 | ||||
| 35. Round | 14/10/2022 | Bray Wanderers | - | Cobh Ramblers | 1:5 |
Ireland