| 1. Round | 15/01/2021 | CS Cartaginés | - | Santos de Guápiles | 1:0 | ||||
| 2. Round | 17/01/2021 | CS Cartaginés | - | Guadalupe | 2:1 | ||||
| 3. Round | 22/01/2021 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | ||||
| 4. Round | 24/01/2021 | CS Cartaginés | - | Limón FC | 1:1 | ||||
| 5. Round | 31/01/2021 | Deportivo Saprissa | - | CS Cartaginés | 4:1 | ||||
| 6. Round | 04/02/2021 | AD San Carlos | - | CS Cartaginés | 1:1 | ||||
| 7. Round | 07/02/2021 | CS Cartaginés | - | CS Herediano | 1:2 | ||||
| 16. Round | 04/04/2021 | CS Cartaginés | - | Deportivo Saprissa | 0:0 | ||||
| 17. Round | 10/04/2021 | CS Cartaginés | - | AD San Carlos | 1:1 | ||||
| 18. Round | 18/04/2021 | CS Herediano | - | CS Cartaginés | 1:2 |  |
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| 19. Round | 21/04/2021 | CS Cartaginés | - | Sporting FC | 0:1 |
Costa Rica