| 2. Round | 23/01/2022 | Atlético Marte | - | Luis Ángel Firpo | 2:1 | ||||
| 3. Round | 27/01/2022 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 4. Round | 30/01/2022 | AD Chalatenango | - | Luis Ángel Firpo | 2:1 | ||||
| 5. Round | 06/02/2022 | Alianza | - | Luis Ángel Firpo | 0:0 | ||||
| 6. Round | 10/02/2022 | Luis Ángel Firpo | - | Platense Zacatecoluca | 1:1 | ||||
| 7. Round | 13/02/2022 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 8. Round | 20/02/2022 | Luis Ángel Firpo | - | CD Águila | 0:0 | ||||
| 9. Round | 23/02/2022 | Jocoro FC | - | Luis Ángel Firpo | 1:1 | ||||
| 10. Round | 27/02/2022 | Luis Ángel Firpo | - | FAS | 2:3 | ||||
| 11. Round | 06/03/2022 | Santa Tecla FC | - | Luis Ángel Firpo | 1:5 | ||||
| 12. Round | 13/03/2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 | ||||
| 13. Round | 20/03/2022 | Luis Ángel Firpo | - | Atlético Marte | 1:2 | ||||
| 14. Round | 24/03/2022 | Isidro Metapán | - | Luis Ángel Firpo | 1:1 | ||||
| 15. Round | 03/04/2022 | Luis Ángel Firpo | - | AD Chalatenango | 1:2 |  |
Costa Rica