| 2. Round | 03/08/2020 | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||||
| 6. Round | 22/08/2020 | Club Necaxa | - | Santos Laguna | 2:1 | ||||
| 7. Round | 31/08/2020 | Santos Laguna | - | Gallos Blancos | 2:1 | ||||
| 8. Round | 05/09/2020 | FC Juárez | - | Santos Laguna | 1:1 | ||||
| 9. Round | 10/09/2020 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 10. Round | 13/09/2020 | UANL Tigres | - | Santos Laguna | 2:0 |  |
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| 11. Round | 20/09/2020 | Deportivo Toluca | - | Santos Laguna | 1:2 | ||||
| 13. Round | 03/10/2020 | Puebla FC | - | Santos Laguna | 0:2 |  |
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| 12. Round | 12/10/2020 | Santos Laguna | - | Club Tijuana | 2:0 | ||||
| 14. Round | 19/10/2020 | Santos Laguna | - | CF Pachuca | 1:1 | ||||
| 15. Round | 26/10/2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 03/11/2020 | Club León | - | Santos Laguna | 2:1 | |
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| 17. Round | 09/11/2020 | Santos Laguna | - | Mazatlán FC | 4:0 |
Mexico