3. Round | 09/02/2022 | Real Madriz | - | Juventus Managua | 0:3 | ||||
7. Round | 03/03/2022 | Diriangén FC | - | Real Madriz | 3:0 | ||||
10. Round | 14/03/2022 | Real Madriz | - | CD Walter Ferretti | 0:2 | ||||
11. Round | 20/03/2022 | Real Estelí FC | - | Real Madriz | 4:0 | ||||
15. Round | 14/04/2022 | Real Madriz | - | Diriangén FC | 2:2 | ||||
16. Round | 25/04/2022 | Real Madriz | - | ART Municipal Jalapa | 3:0 dec. |