| 1. Round | 18/07/2021 | Spartak Subotica | - | Radnički Niš | 1:1 |  |
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| 2. Round | 23/07/2021 | FK Radnički 1923 | - | Spartak Subotica | 3:2 | ||||
| 3. Round | 31/07/2021 | Spartak Subotica | - | Crvena Zvezda | 1:3 | ||||
| 5. Round | 16/08/2021 | Spartak Subotica | - | Vojvodina | 2:2 | ||||
| 6. Round | 22/08/2021 | Spartak Subotica | - | FK Napredak | 3:2 | ||||
| 7. Round | 28/08/2021 | Radnik Surdulica | - | Spartak Subotica | 1:2 | |
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| 8. Round | 10/09/2021 | Spartak Subotica | - | TSC Bačka Topola | 0:0 | |
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| 9. Round | 18/09/2021 | FK Čukarički | - | Spartak Subotica | 2:1 | ||||
| 11. Round | 26/09/2021 | Partizan | - | Spartak Subotica | 5:0 | ||||
| 12. Round | 02/10/2021 | Spartak Subotica | - | FK Voždovac | 0:4 | ||||
| 13. Round | 15/10/2021 | FK Novi Pazar | - | Spartak Subotica | 0:1 | ||||
| 14. Round | 23/10/2021 | Spartak Subotica | - | FK Metalac | 2:0 | ||||
| 19. Round | 05/12/2021 | Spartak Subotica | - | Mladost Lučani | 0:0 | |
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| 21. Round | 18/12/2021 | FK Napredak | - | Spartak Subotica | 1:0 |
Italy