| 2. Round | 10/08/2021 | Diriangén FC | - | Juventus Managua | 2:0 | ||||
| 4. Round | 23/08/2021 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 | ||||
| 5. Round | 30/08/2021 | Managua FC | - | Diriangén FC | 1:2 | ||||
| 6. Round | 02/09/2021 | Real Madriz | - | Diriangén FC | 0:1 |  |
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| 7. Round | 13/09/2021 | Diriangén FC | - | Real Estelí FC | 3:2 | ||||
| 8. Round | 19/09/2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 3. Round | 23/09/2021 | CD Walter Ferretti | - | Diriangén FC | 2:3 | ||||
| 9. Round | 27/09/2021 | ART Municipal Jalapa | - | Diriangén FC | 2:1 | ||||
| 10. Round | 02/10/2021 | UNAN Managua | - | Diriangén FC | 0:5 | ||||
| 11. Round | 10/10/2021 | Juventus Managua | - | Diriangén FC | 2:0 | |
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| 18. Round | 22/11/2021 | Diriangén FC | - | ART Municipal Jalapa | 5:0 |
Nicaragua