| 1. Round | 23/01/2022 | Juventus Managua | - | Managua FC | 1:2 |  |
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| 2. Round | 05/02/2022 | Juventus Managua | - | Diriangén FC | 0:2 |  |
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| 4. Round | 13/02/2022 | Real Estelí FC | - | Juventus Managua | 2:1 | ||||
| 9. Round | 10/03/2022 | UNAN Managua | - | Juventus Managua | 1:2 | ||||
| 13. Round | 07/04/2022 | Juventus Managua | - | Real Estelí FC | 0:3 | ||||
| 14. Round | 09/04/2022 | H&H Export Sébaco | - | Juventus Managua | 2:0 | ||||
| 15. Round | 14/04/2022 | CD Walter Ferretti | - | Juventus Managua | 2:1 | ||||
| 16. Round | 25/04/2022 | Juventus Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 |
Nicaragua