| 3. Round | 03/10/2021 | CE Carroi | - | FC Santa Coloma | 2:5 | ||||
| 4. Round | 17/10/2021 | FC Santa Coloma | - | FC Ordino | 3:2 | ||||
| 5. Round | 24/10/2021 | FC Santa Coloma | - | UE Sant Julià | 1:3 | ||||
| 7. Round | 07/11/2021 | FC Santa Coloma | - | Atlétic Escaldes | 1:3 | ||||
| 9. Round | 28/11/2021 | UE Engordany | - | FC Santa Coloma | 2:4 | ||||
| 10. Round | 19/12/2021 | FC Santa Coloma | - | CE Carroi | 3:0 | ||||
| 12. Round | 19/01/2022 | UE Sant Julià | - | FC Santa Coloma | 0:0 | ||||
| 8. Round | 26/01/2022 | FC Santa Coloma | - | UE Santa Coloma | 3:1 | ||||
| 13. Round | 30/01/2022 | FC Santa Coloma | - | Inter Club d'Escaldes | 3:2 |  |
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| 11. Round | 02/02/2022 | FC Ordino | - | FC Santa Coloma | 0:0 | ||||
| 14. Round | 06/02/2022 | Atlétic Escaldes | - | FC Santa Coloma | 2:1 | ||||
| 16. Round | 20/02/2022 | FC Santa Coloma | - | UE Engordany | 1:1 | ||||
| 17. Round | 27/02/2022 | CE Carroi | - | FC Santa Coloma | 0:5 | ||||
| 18. Round | 06/03/2022 | FC Santa Coloma | - | FC Ordino | 2:1 | ||||
| 19. Round | 13/03/2022 | FC Santa Coloma | - | UE Sant Julià | 2:0 | |
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| 20. Round | 20/03/2022 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:2 |  |
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| 21. Round | 03/04/2022 | FC Santa Coloma | - | Atlétic Escaldes | 1:1 |
Spain