| 1. Round | 01/08/2021 | Managua FC | - | Juventus Managua | 0:1 |  |
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| 2. Round | 10/08/2021 | Diriangén FC | - | Juventus Managua | 2:0 | ||||
| 3. Round | 16/08/2021 | Real Madriz | - | Juventus Managua | 2:0 | ||||
| 4. Round | 21/08/2021 | Juventus Managua | - | Real Estelí FC | 1:3 | ||||
| 5. Round | 29/08/2021 | Juventus Managua | - | H&H Export Sébaco | 1:0 |  |
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| 6. Round | 02/09/2021 | CD Walter Ferretti | - | Juventus Managua | 2:0 | ||||
| 7. Round | 13/09/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
| 8. Round | 20/09/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 9. Round | 27/09/2021 | UNAN Managua | - | Juventus Managua | 1:1 | ||||
| 10. Round | 02/10/2021 | Juventus Managua | - | Managua FC | 1:3 | ||||
| 17. Round | 19/11/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:1 | ||||
| 18. Round | 21/11/2021 | Juventus Managua | - | UNAN Managua | 1:2 |
Colombia