| 5. Round | 11/09/2010 | RC Lens | - | Lille OSC | 1:4 | ||||
| 6. Round | 19/09/2010 | Lille OSC | - | AJ Auxerre | 1:0 | ||||
| 7. Round | 26/09/2010 | Toulouse FC | - | Lille OSC | 1:1 | ||||
| 8. Round | 03/10/2010 | Lille OSC | - | Montpellier HSC | 3:1 | ||||
| 9. Round | 17/10/2010 | Olympique Lyonnais | - | Lille OSC | 3:1 | ||||
| 12. Round | 07/11/2010 | Lille OSC | - | Stade Brestois 29 | 3:1 | ||||
| 13. Round | 13/11/2010 | SM Caen | - | Lille OSC | 2:5 | ||||
| 14. Round | 21/11/2010 | Lille OSC | - | AS Monaco | 2:1 | ||||
| 23. Round | 13/02/2011 | Lille OSC | - | Toulouse FC | 2:0 | ||||
| 29. Round | 02/04/2011 | Lille OSC | - | SM Caen | 3:1 | ||||
| 33. Round | 30/04/2011 | Lille OSC | - | AC Arles-Avignon | 5:0 |  |
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| 34. Round | 07/05/2011 | AS Nancy Lorraine | - | Lille OSC | 0:1 | |
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| 35. Round | 10/05/2011 | AS Saint-Étienne | - | Lille OSC | 1:2 |
Czech Republic