| 5. Round | 10/09/2011 | AS Saint-Étienne | - | Lille OSC | 1:3 | ||||
| 7. Round | 20/09/2011 | Girondins Bordeaux | - | Lille OSC | 1:1 |  |
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| 8. Round | 24/09/2011 | Lille OSC | - | FC Lorient | 1:1 | |
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| 9. Round | 02/10/2011 | Lille OSC | - | Stade Rennais | 2:0 | ||||
| 10. Round | 15/10/2011 | AJ Auxerre | - | Lille OSC | 1:3 | ||||
| 12. Round | 30/10/2011 | Valenciennes FC | - | Lille OSC | 0:0 | ||||
| 14. Round | 18/11/2011 | Toulouse FC | - | Lille OSC | 0:0 | |
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| 15. Round | 26/11/2011 | Lille OSC | - | Stade Brestois 29 | 2:0 | |
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| 19. Round | 21/12/2011 | Lille OSC | - | OGC Nice | 4:4 | |
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| 20. Round | 15/01/2012 | Olympique Marseille | - | Lille OSC | 2:0 | ||||
| 21. Round | 28/01/2012 | Lille OSC | - | AS Saint-Étienne | 3:0 | |
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| 23. Round | 12/02/2012 | Lille OSC | - | Girondins Bordeaux | 4:5 |  |
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| 22. Round | 22/02/2012 | FC Sochaux | - | Lille OSC | 0:1 | ||||
| 26. Round | 03/03/2012 | Lille OSC | - | AJ Auxerre | 2:2 | ||||
| 30. Round | 01/04/2012 | Lille OSC | - | Toulouse FC | 2:1 |
Czech Republic