| Group 1 | 01/11/2020 | Sonsonate FC | - | Once Municipal | 0:1 | ||||
| Group 1 | 08/11/2020 | Once Municipal | - | Isidro Metapán | 3:1 |  |
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| Group 1 | 15/11/2020 | FAS | - | Once Municipal | 1:0 |  |
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| Group B | 22/11/2020 | Once Municipal | - | Santa Tecla FC | 2:0 | |
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| Group B | 25/11/2020 | Municipal Limeño | - | Once Municipal | 1:0 | ||||
| Group B | 29/11/2020 | Once Municipal | - | FAS | 4:2 | |
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| Group B | 06/12/2020 | Luis Ángel Firpo | - | Once Municipal | 0:1 | ||||
| Group B | 13/12/2020 | Once Municipal | - | AD Chalatenango | 1:0 | ||||
| Group B | 19/12/2020 | Santa Tecla FC | - | Once Municipal | 1:1 | |
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| Group B | 23/12/2020 | Once Municipal | - | Municipal Limeño | 0:1 | ||||
| Group B | 27/12/2020 | FAS | - | Once Municipal | 0:1 | ||||
| Group B | 03/01/2021 | Once Municipal | - | Luis Ángel Firpo | 1:1 | |
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| Quarter-finals | 13/01/2021 | Once Municipal | - | Alianza | 1:2 | |
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| Quarter-finals | 17/01/2021 | Alianza | - | Once Municipal | 3:1 |
El Salvador