| Round of 16 | 22/04/2022 | Millonarios | - | Jaguares de Córdoba | 3:0 |  |
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| Quarter-finals | 28/07/2022 | Millonarios | - | Fortaleza FC | 3:0 | ||||
| Quarter-finals | 18/08/2022 | Fortaleza FC | - | Millonarios | 2:3 | ||||
| Semi-finals | 25/08/2022 | Independiente Medellín | - | Millonarios | 0:2 | |
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| Semi-finals | 08/09/2022 | Millonarios | - | Independiente Medellín | 2:2 |  |
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| Final | 29/09/2022 | Atlético Junior | - | Millonarios | 1:0 | ||||
| Final | 03/11/2022 | Millonarios | - | Atlético Junior | 2:0 | |
Colombia