| 1. Round | 18/09/2021 | SS Folgore/Falciano | - | FC Domagnano | 0:1 | ||||
| 2. Round | 25/09/2021 | FC Domagnano | - | SP Cailungo | 3:0 | ||||
| 3. Round | 03/10/2021 | FC Domagnano | - | FC Fiorentino | 3:0 | ||||
| 5. Round | 19/10/2021 | AC Juvenes/Dogana | - | FC Domagnano | 2:1 | ||||
| 7. Round | 30/10/2021 | SC Faetano | - | FC Domagnano | 2:1 | ||||
| 12. Round | 11/12/2021 | FC Domagnano | - | SP La Fiorita | 1:2 | ||||
| 18. Round | 30/01/2022 | FC Fiorentino | - | FC Domagnano | 1:3 | ||||
| 19. Round | 06/02/2022 | FC Domagnano | - | SS Virtus | 0:0 | ||||
| 20. Round | 12/02/2022 | FC Domagnano | - | AC Juvenes/Dogana | 0:2 | ||||
| 21. Round | 16/02/2022 | SP Tre Fiori | - | FC Domagnano | 1:1 | ||||
| 22. Round | 20/02/2022 | FC Domagnano | - | SC Faetano | 1:3 | ||||
| 14. Round | 23/02/2022 | FC Domagnano | - | AC Libertas | 3:1 | ||||
| 23. Round | 26/02/2022 | SS Pennarossa | - | FC Domagnano | 1:0 | ||||
| 16. Round | 02/04/2022 | FC Domagnano | - | SS Folgore/Falciano | 1:0 | ||||
| 17. Round | 05/04/2022 | SP Cailungo | - | FC Domagnano | 1:1 | ||||
| 28. Round | 10/04/2022 | FC Domagnano | - | SP Tre Penne | 2:3 | ||||
| 29. Round | 14/04/2022 | AC Libertas | - | FC Domagnano | 1:0 | ||||
| 30. Round | 20/04/2022 | FC Domagnano | - | SS San Giovanni | 0:4 |
San Marino
Italy