| 1. Round | 11/09/2021 | Panathinaikos | - | Apollon Smyrnis | 4:0 | ||||
| 2. Round | 19/09/2021 | Apollon Smyrnis | - | Volos NFC | 1:3 | ||||
| 16. Round | 05/01/2022 | Apollon Smyrnis | - | Olympiakos Piraeus | 0:0 |  |
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| 13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
| 18. Round | 15/01/2022 | Apollon Smyrnis | - | Aris Saloniki | 0:0 | ||||
| 15. Round | 19/01/2022 | Volos NFC | - | Apollon Smyrnis | 1:0 | ||||
| 19. Round | 24/01/2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | ||||
| 20. Round | 30/01/2022 | PAS Giannina | - | Apollon Smyrnis | 2:0 | ||||
| 21. Round | 02/02/2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | ||||
| 22. Round | 06/02/2022 | AEK Athen | - | Apollon Smyrnis | 3:0 | ||||
| 23. Round | 12/02/2022 | Apollon Smyrnis | - | Panetolikos | 0:0 | ||||
| 14. Round | 16/02/2022 | Apollon Smyrnis | - | Panathinaikos | 0:3 |
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