| 1. Round | 07/08/2010 | Tranmere Rovers | - | Oldham Athletic | 1:2 | ||||
| 2. Round | 14/08/2010 | Oldham Athletic | - | Notts County | 3:0 | ||||
| 4. Round | 28/08/2010 | Oldham Athletic | - | Yeovil Town | 0:0 | ||||
| 5. Round | 04/09/2010 | Oldham Athletic | - | Bristol Rovers | 1:1 | ||||
| 6. Round | 11/09/2010 | Peterborough United | - | Oldham Athletic | 5:2 | ||||
| 7. Round | 18/09/2010 | Oldham Athletic | - | AFC Bournemouth | 2:1 | ||||
| 8. Round | 25/09/2010 | Brighton & Hove Albion | - | Oldham Athletic | 2:1 | ||||
| 11. Round | 09/10/2010 | Brentford FC | - | Oldham Athletic | 1:3 | ||||
| 12. Round | 16/10/2010 | Oldham Athletic | - | Colchester United | 0:0 | ||||
| 13. Round | 23/10/2010 | Southampton FC | - | Oldham Athletic | 2:1 | ||||
| 14. Round | 30/10/2010 | Oldham Athletic | - | Plymouth Argyle | 4:2 |  |
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| 16. Round | 13/11/2010 | Oldham Athletic | - | Huddersfield Town | 1:0 | ||||
| 15. Round | 27/11/2010 | Rochdale AFC | - | Oldham Athletic | 1:1 |  |
Ireland