| 2. Round | 20/08/2021 | Connah's Quay Nomads | - | Aberystwyth Town | 1:0 | ||||
| 6. Round | 18/09/2021 | Connah's Quay Nomads | - | Bala Town | 0:1 | ||||
| 7. Round | 02/10/2021 | Haverfordwest County | - | Connah's Quay Nomads | 1:1 | ||||
| 8. Round | 09/10/2021 | Connah's Quay Nomads | - | The New Saints | 0:1 | ||||
| 9. Round | 12/10/2021 | Connah's Quay Nomads | - | Newtown AFC | 0:2 | ||||
| 10. Round | 23/10/2021 | Cardiff Metropolitan | - | Connah's Quay Nomads | 1:1 | ||||
| 11. Round | 29/10/2021 | Connah's Quay Nomads | - | Cefn Druids | 4:0 | ||||
| 12. Round | 05/11/2021 | Bala Town | - | Connah's Quay Nomads | 0:4 | ||||
| 13. Round | 09/11/2021 | Caernarfon Town | - | Connah's Quay Nomads | 0:1 | ||||
| 14. Round | 20/11/2021 | Connah's Quay Nomads | - | Penybont FC | 0:0 | ||||
| 15. Round | 03/12/2021 | Aberystwyth Town | - | Connah's Quay Nomads | 0:1 |  |
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| 16. Round | 11/12/2021 | Connah's Quay Nomads | - | Cardiff Metropolitan | 0:0 | ||||
| 17. Round | 18/12/2021 | Connah's Quay Nomads | - | Haverfordwest County | 1:0 | ||||
| 19. Round | 11/02/2022 | Connah's Quay Nomads | - | Flint Town United | 2:0 | ||||
| 22. Round | 26/02/2022 | Newtown AFC | - | Connah's Quay Nomads | 0:2 | |
England