| 5. Round | 20/08/2018 | Santos Laguna | - | UANL Tigres | 3:1 | ||||
| 6. Round | 23/08/2018 | Club Tijuana | - | Santos Laguna | 2:2 | ||||
| 7. Round | 27/08/2018 | Santos Laguna | - | Cruz Azul | 1:1 |  |
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| 8. Round | 02/09/2018 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 10. Round | 24/09/2018 | Santos Laguna | - | CD Veracruz | 1:1 | ||||
| 14. Round | 27/10/2018 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 15. Round | 04/11/2018 | Gallos Blancos | - | Santos Laguna | 2:1 | ||||
| 16. Round | 12/11/2018 | Santos Laguna | - | CF América | 1:1 |
Colombia