| 2. Round | 24/08/2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Round | 12/09/2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Round | 19/09/2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 5. Round | 25/09/2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 6. Round | 03/10/2021 | Mamelodi Sundowns | - | Moroka Swallows | 3:0 | ||||
| 7. Round | 20/10/2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 11. Round | 20/11/2021 | Cape Town City FC | - | Mamelodi Sundowns | 0:0 | ||||
| 19. Round | 24/11/2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 12. Round | 27/11/2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 |  |
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| 15. Round | 11/12/2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 | ||||
| 22. Round | 14/12/2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 | ||||
| 16. Round | 17/12/2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Round | 20/12/2021 | AmaZulu FC | - | Mamelodi Sundowns | 1:0 | ||||
| 8. Round | 14/02/2022 | Baroka FC | - | Mamelodi Sundowns | 1:1 | ||||
| 25. Round | 12/04/2022 | Mamelodi Sundowns | - | Golden Arrows | 6:0 | ||||
| 26. Round | 27/04/2022 | Mamelodi Sundowns | - | Cape Town City FC | 0:0 |
Uganda