| 3. Round | 15/08/2021 | 1. FC Heidenheim 1846 | - | Hansa Rostock | 1:1 | ||||
| 4. Round | 20/08/2021 | Hannover 96 | - | 1. FC Heidenheim 1846 | 1:0 | ||||
| 5. Round | 28/08/2021 | 1. FC Heidenheim 1846 | - | Hamburger SV | 0:0 | ||||
| 6. Round | 12/09/2021 | 1. FC Heidenheim 1846 | - | Dynamo Dresden | 2:1 | ||||
| 7. Round | 18/09/2021 | SV Sandhausen | - | 1. FC Heidenheim 1846 | 1:3 | ||||
| 8. Round | 24/09/2021 | 1. FC Heidenheim 1846 | - | SV Darmstadt 98 | 2:1 | ||||
| 9. Round | 01/10/2021 | Werder Bremen | - | 1. FC Heidenheim 1846 | 3:0 | ||||
| 10. Round | 16/10/2021 | 1. FC Heidenheim 1846 | - | FC St. Pauli | 2:4 | ||||
| 12. Round | 29/10/2021 | 1. FC Heidenheim 1846 | - | FC Schalke 04 | 1:0 | ||||
| 13. Round | 07/11/2021 | Erzgebirge Aue | - | 1. FC Heidenheim 1846 | 2:0 | ||||
| 19. Round | 16/01/2022 | 1. FC Heidenheim 1846 | - | FC Ingolstadt 04 | 2:1 | ||||
| 20. Round | 22/01/2022 | Hansa Rostock | - | 1. FC Heidenheim 1846 | 0:0 | ||||
| 23. Round | 18/02/2022 | Dynamo Dresden | - | 1. FC Heidenheim 1846 | 1:1 | ||||
| 24. Round | 27/02/2022 | 1. FC Heidenheim 1846 | - | SV Sandhausen | 1:1 | ||||
| 25. Round | 04/03/2022 | SV Darmstadt 98 | - | 1. FC Heidenheim 1846 | 3:2 |
Germany
Poland