| 7. Round | 11/09/2010 | 1899 Hoffenheim II | - | Stuttgarter Kickers | 1:1 | ||||
| 10. Round | 26/09/2010 | 1899 Hoffenheim II | - | TSV 1860 München II | 2:0 | ||||
| 11. Round | 03/10/2010 | SV Wehen Wiesbaden II | - | 1899 Hoffenheim II | 2:5 | ||||
| 14. Round | 29/10/2010 | 1899 Hoffenheim II | - | Hessen Kassel | 3:0 | ||||
| 15. Round | 05/11/2010 | Karlsruher SC II | - | 1899 Hoffenheim II | 1:0 | ||||
| 17. Round | 19/11/2010 | Eintracht Frankfurt II | - | 1899 Hoffenheim II | 1:1 | ||||
| 18. Round | 28/11/2010 | 1899 Hoffenheim II | - | Wormatia Worms | 1:2 | ||||
| 19. Round | 05/12/2010 | FSV Frankfurt II | - | 1899 Hoffenheim II | 1:3 | ||||
| 20. Round | 12/12/2010 | 1899 Hoffenheim II | - | SC Pfullendorf | 1:2 |  |
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| 22. Round | 26/02/2011 | SG Sonnenhof Großaspach | - | 1899 Hoffenheim II | 1:1 | ||||
| 23. Round | 06/03/2011 | 1899 Hoffenheim II | - | SV Darmstadt 98 | 1:1 | |
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| 25. Round | 20/03/2011 | 1899 Hoffenheim II | - | 1. FC Nürnberg II | 1:0 | ||||
| 28. Round | 17/04/2011 | 1899 Hoffenheim II | - | SV Wehen Wiesbaden II | 5:1 |
Germany
Poland