| 1. Round | 17/02/2021 | Honduras Progreso | - | Marathón | 1:1 | ||||
| 2. Round | 20/02/2021 | Marathón | - | Motagua | 0:1 | ||||
| 3. Round | 24/02/2021 | Vida | - | Marathón | 0:1 | ||||
| 4. Round | 27/02/2021 | Marathón | - | Real España | 1:2 | ||||
| 5. Round | 03/03/2021 | Platense | - | Marathón | 5:3 | ||||
| 6. Round | 07/03/2021 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 7. Round | 12/03/2021 | Motagua | - | Marathón | 2:0 | ||||
| 8. Round | 17/03/2021 | Marathón | - | Vida | 1:2 | ||||
| 9. Round | 21/03/2021 | Real España | - | Marathón | 2:2 | ||||
| 10. Round | 03/04/2021 | Marathón | - | Platense | 1:0 |  |
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| 11. Round | 09/04/2021 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 12. Round | 17/04/2021 | Real Sociedad | - | Marathón | 1:1 | |
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| 13. Round | 21/04/2021 | Marathón | - | Real de Minas | 3:2 | ||||
| 14. Round | 28/04/2021 | Olimpia | - | Marathón | 2:1 | |
Honduras