| 1. Round | 01/08/2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 2. Round | 07/08/2022 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
| 3. Round | 11/08/2022 | Victoria | - | Lobos UPNFM | 4:0 | ||||
| 4. Round | 14/08/2022 | Lobos UPNFM | - | Honduras Progreso | 1:2 | ||||
| 5. Round | 21/08/2022 | Lobos UPNFM | - | Motagua | 2:3 | ||||
| 6. Round | 28/08/2022 | Olimpia | - | Lobos UPNFM | 2:0 | ||||
| 11. Round | 02/10/2022 | Real Sociedad | - | Lobos UPNFM | 0:2 | ||||
| 12. Round | 09/10/2022 | Lobos UPNFM | - | Victoria | 2:2 |  |
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| 13. Round | 16/10/2022 | Honduras Progreso | - | Lobos UPNFM | 2:2 | ||||
| 15. Round | 23/10/2022 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 17. Round | 13/11/2022 | Lobos UPNFM | - | Marathón | 2:1 |
Honduras