| 1. Round | 30/01/2011 | Club Nacional | - | Club Olimpia | 1:2 | ||||
| 2. Round | 06/02/2011 | Independiente CG | - | Club Olimpia | 0:3 | ||||
| 3. Round | 12/02/2011 | Club Olimpia | - | General Caballero ZC | 3:1 | ||||
| 4. Round | 16/02/2011 | Sol de América | - | Club Olimpia | 0:4 | ||||
| 6. Round | 26/02/2011 | Cerro Porteño | - | Club Olimpia | 1:2 | ||||
| 7. Round | 05/03/2011 | Club Olimpia | - | Guaraní | 4:3 | ||||
| 8. Round | 08/03/2011 | Tacuary | - | Club Olimpia | 0:0 | ||||
| 9. Round | 13/03/2011 | Club Olimpia | - | Club Rubio Ñu | 1:3 | ||||
| 11. Round | 27/03/2011 | Club Olimpia | - | 3 de Febrero | 3:1 | ||||
| 15. Round | 23/04/2011 | Club Olimpia | - | Sol de América | 2:0 |
Paraguay