| 1. Round | 28/09/2020 | Real España | - | Olimpia | 1:1 | ||||
| 2. Round | 07/10/2020 | Platense | - | Real España | 1:0 | ||||
| 3. Round | 12/10/2020 | Real España | - | Honduras Progreso | 5:0 | ||||
| 4. Round | 14/10/2020 | Marathón | - | Real España | 3:0 | ||||
| 5. Round | 19/10/2020 | Real España | - | Vida | 0:3 | ||||
| 7. Round | 26/10/2020 | Real España | - | Platense | 3:2 |  |
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| 13. Round | 15/11/2020 | Lobos UPNFM | - | Real España | 1:1 | ||||
| 11. Round | 26/11/2020 | Real España | - | Real de Minas | 1:1 | ||||
| 12. Round | 29/11/2020 | Real España | - | Motagua | 0:1 |
Honduras