| 1. Round | 01/08/2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 2. Round | 08/08/2022 | Real España | - | Motagua | 1:1 | ||||
| 3. Round | 10/08/2022 | Real Sociedad | - | Real España | 2:1 |  |
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| 4. Round | 15/08/2022 | Real España | - | Victoria | 2:1 | ||||
| 5. Round | 21/08/2022 | Olimpia | - | Real España | 1:1 | |
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| 6. Round | 29/08/2022 | Real España | - | Marathón | 2:0 | ||||
| 7. Round | 01/09/2022 | Vida | - | Real España | 1:0 | |
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| 9. Round | 12/09/2022 | Real España | - | Honduras Progreso | 2:0 | ||||
| 10. Round | 18/09/2022 | Lobos UPNFM | - | Real España | 2:2 | ||||
| 11. Round | 02/10/2022 | Motagua | - | Real España | 1:2 | ||||
| 12. Round | 08/10/2022 | Real España | - | Real Sociedad | 1:3 | |
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| 14. Round | 20/10/2022 | Real España | - | Olimpia | 0:0 | ||||
| 15. Round | 23/10/2022 | Marathón | - | Real España | 2:0 | |
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| 16. Round | 06/11/2022 | Real España | - | Vida | 2:1 | ||||
| 17. Round | 13/11/2022 | Real España | - | Olancho FC | 4:3 | |
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| 18. Round | 19/11/2022 | Honduras Progreso | - | Real España | 0:0 |
Honduras