| 6. Round | 07/08/2022 | Fortaleza FC | - | Real Cartagena | 3:1 | ||||
| 9. Round | 31/08/2022 | Real Cartagena | - | Barranquilla FC | 2:2 | ||||
| 10. Round | 03/09/2022 | Valledupar FC | - | Real Cartagena | 1:1 | ||||
| 14. Round | 24/09/2022 | Barranquilla FC | - | Real Cartagena | 2:3 |  |
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| 15. Round | 01/10/2022 | Real Cartagena | - | Boca Juniors de Cali | 0:0 |
Colombia