| 1. Round | 24/01/2020 | Deportes Tolima | - | Independiente Medellín | 2:2 |  |
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| 2. Round | 28/01/2020 | Independiente Medellín | - | Águilas Doradas | 2:1 | ||||
| 5. Round | 15/02/2020 | América de Cali | - | Independiente Medellín | 2:0 | ||||
| 7. Round | 29/02/2020 | Atlético Nacional | - | Independiente Medellín | 1:1 | ||||
| 8. Round | 07/03/2020 | Independiente Medellín | - | Millonarios | 1:0 | ||||
| 9. Round | 20/09/2020 | Alianza Petrolera | - | Independiente Medellín | 1:0 | ||||
| 10. Round | 28/09/2020 | Independiente Medellín | - | Deportivo Pereira | 1:1 | ||||
| 16. Round | 26/10/2020 | Independiente Medellín | - | Deportivo Cali | 2:3 | ||||
| 17. Round | 02/11/2020 | Independiente Medellín | - | Once Caldas | 1:1 | |
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| 18. Round | 06/11/2020 | Santa Fe | - | Independiente Medellín | 3:0 | ||||
| 19. Round | 10/11/2020 | Independiente Medellín | - | Atlético Bucaramanga | 1:0 | ||||
| 20. Round | 14/11/2020 | Envigado FC | - | Independiente Medellín | 2:1 |
Colombia