| 4. Round | 04/02/2021 | Club Deportivo Ocotal | - | Chinandega | 0:0 | ||||
| 5. Round | 07/02/2021 | Real Madriz | - | Club Deportivo Ocotal | 1:2 |  |
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| 6. Round | 11/02/2021 | Club Deportivo Ocotal | - | Juventus Managua | 1:0 | ||||
| 7. Round | 14/02/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 3:3 | ||||
| 8. Round | 18/02/2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
| 9. Round | 01/03/2021 | Diriangén FC | - | Club Deportivo Ocotal | 0:1 | ||||
| 10. Round | 07/03/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 1:1 | ||||
| 11. Round | 15/03/2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 | |
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| 12. Round | 01/04/2021 | Club Deportivo Ocotal | - | Junior Managua | 2:1 | ||||
| 13. Round | 11/04/2021 | Chinandega | - | Club Deportivo Ocotal | 2:1 |  |
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| 14. Round | 18/04/2021 | Club Deportivo Ocotal | - | Real Madriz | 1:1 | |
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| 15. Round | 25/04/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
| 16. Round | 30/04/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | |
Colombia