| 4. Round | 30/07/2021 | Patronato de Paraná II | - | Newell's Old Boys II | 1:2 | ||||
| 6. Round | 16/08/2021 | Racing Club II | - | Newell's Old Boys II | 1:1 | ||||
| 7. Round | 20/08/2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 9. Round | 30/08/2021 | Newell's Old Boys II | - | Atlético Tucumán II | 2:3 | ||||
| 10. Round | 03/09/2021 | Colón de Santa Fe II | - | Newell's Old Boys II | 1:1 | ||||
| 11. Round | 10/09/2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Round | 17/09/2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 14. Round | 01/10/2021 | Godoy Cruz II | - | Newell's Old Boys II | 1:1 |  |
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| 18. Round | 22/10/2021 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 | ||||
| 21. Round | 17/11/2021 | Arsenal de Sarandí II | - | Newell's Old Boys II | 0:3 |
Argentina