| 4. Round | 26/01/2021 | Guadalupe | - | Deportivo Saprissa | 2:2 | ||||
| 5. Round | 01/02/2021 | Santos de Guápiles | - | Guadalupe | 2:2 | ||||
| 7. Round | 06/02/2021 | Guadalupe | - | Sporting FC | 0:0 | ||||
| 8. Round | 16/02/2021 | Municipal Pérez Zeledón | - | Guadalupe | 1:3 | ||||
| 11. Round | 04/03/2021 | Guadalupe | - | LD Alajuelense | 1:3 | ||||
| 12. Round | 06/03/2021 | Limón FC | - | Guadalupe | 1:7 |  |
Mexico