| 1. Round | 26/08/2022 | Inter Playa | - | Deportivo Dongu | 1:0 | ||||
| 3. Round | 07/09/2022 | Inter Playa | - | Sporting Canamy | 1:1 |  |
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| 4. Round | 11/09/2022 | Deportivo Venados | - | Inter Playa | 2:1 | ||||
| 5. Round | 16/09/2022 | Inter Playa | - | Cafetaleros de Chiapas | 3:4 |  |
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| 6. Round | 25/09/2022 | Montañeses FC | - | Inter Playa | 2:2 | ||||
| 8. Round | 02/10/2022 | CF Pachuca II | - | Inter Playa | 2:0 | ||||
| 9. Round | 07/10/2022 | Inter Playa | - | Yalmakan FC | 1:2 | ||||
| 10. Round | 14/10/2022 | Inter Playa | - | Leviatán FC | 4:0 | |
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| 11. Round | 22/10/2022 | Escorpiones | - | Inter Playa | 2:3 |
Panama