| 1. Round | 28/08/2005 | Panionios GSS | - | AE Lárissa | 1:1 | ||||
| 2. Round | 10/09/2005 | Olympiakos Piraeus | - | Panionios GSS | 5:0 | ||||
| 4. Round | 24/09/2005 | Panathinaikos | - | Panionios GSS | 3:0 | ||||
| 8. Round | 31/10/2005 | Panionios GSS | - | AEK Athen | 0:2 | ||||
| 9. Round | 06/11/2005 | PAOK Saloniki | - | Panionios GSS | 1:0 | ||||
| 10. Round | 20/11/2005 | Panionios GSS | - | OFI Heraklion | 1:1 | ||||
| 11. Round | 27/11/2005 | Apollon Kalamarias | - | Panionios GSS | 1:0 | ||||
| 12. Round | 05/12/2005 | Panionios GSS | - | Skoda Xanthi | 0:2 |  |
|||
| 13. Round | 11/12/2005 | Panionios GSS | - | Atromitos | 2:0 | |
|||
| 14. Round | 18/12/2005 | Iraklis Saloniki | - | Panionios GSS | 1:0 | |
South Africa