| 19. Round | 13/02/2022 | KF Shkupi | - | FK AP Brera Strumica | 2:1 |  |
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| 20. Round | 20/02/2022 | FK AP Brera Strumica | - | FK Skopje | 5:0 | ||||
| 21. Round | 27/02/2022 | KF Shkëndija 79 | - | FK AP Brera Strumica | 0:0 | ||||
| 22. Round | 09/03/2022 | FK AP Brera Strumica | - | FK Borec | 5:0 | ||||
| 23. Round | 13/03/2022 | FK AP Brera Strumica | - | FC Struga | 1:0 | ||||
| 24. Round | 19/03/2022 | GFK Tikvesh | - | FK AP Brera Strumica | 1:2 |  |
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| 25. Round | 03/04/2022 | FK AP Brera Strumica | - | FK Skopje | 1:2 | ||||
| 26. Round | 06/04/2022 | FK Borec | - | FK AP Brera Strumica | 1:1 | ||||
| 27. Round | 10/04/2022 | FK AP Brera Strumica | - | FK Pelister | 2:0 | |
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| 28. Round | 17/04/2022 | FK Renova | - | FK AP Brera Strumica | 0:1 | ||||
| 29. Round | 22/04/2022 | FK AP Brera Strumica | - | FK Bregalnica Štip | 2:1 | ||||
| 30. Round | 01/05/2022 | Makedonija GP | - | FK AP Brera Strumica | 1:0 | |
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| 31. Round | 04/05/2022 | FK AP Brera Strumica | - | KF Shkëndija 79 | 4:2 | ||||
| 32. Round | 08/05/2022 | FK AP Brera Strumica | - | FK Rabotnički | 2:1 | ||||
| 33. Round | 15/05/2022 | KF Shkupi | - | FK AP Brera Strumica | 3:0 |
North Macedonia