| 5. Round | 22/08/2021 | Lokomotiv Plovdiv | - | Slavia Sofia | 0:1 | ||||
| 6. Round | 27/08/2021 | Slavia Sofia | - | CSKA 1948 Sofia | 2:1 | ||||
| 7. Round | 11/09/2021 | CSKA Sofia | - | Slavia Sofia | 1:1 | ||||
| 8. Round | 19/09/2021 | Slavia Sofia | - | PFC Ludogorets Razgrad | 1:0 | ||||
| 9. Round | 27/09/2021 | Lokomotiv Sofia | - | Slavia Sofia | 1:0 |  |
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| 11. Round | 17/10/2021 | Cherno More Varna | - | Slavia Sofia | 1:1 | ||||
| 12. Round | 23/10/2021 | Arda Kardzhali | - | Slavia Sofia | 1:1 | ||||
| 13. Round | 30/10/2021 | Slavia Sofia | - | Botev Vratsa | 1:0 | ||||
| 19. Round | 11/12/2021 | CSKA 1948 Sofia | - | Slavia Sofia | 1:1 | ||||
| 20. Round | 20/02/2022 | Slavia Sofia | - | CSKA Sofia | 2:3 | ||||
| 26. Round | 08/04/2022 | Botev Vratsa | - | Slavia Sofia | 2:1 |
Bulgaria