| 1. Round | 16/09/2000 | Panachaiki GE | - | Skoda Xanthi | 1:1 | ||||
| 2. Round | 23/09/2000 | Iraklis Saloniki | - | Panachaiki GE | 2:0 |  |
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| 3. Round | 30/09/2000 | Panachaiki GE | - | Athinaikos | 3:1 | ||||
| 4. Round | 29/10/2000 | Ethnikos Asteras | - | Panachaiki GE | 3:1 | |
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| 5. Round | 05/11/2000 | Panachaiki GE | - | Ionikos Nikea | 2:3 | ||||
| 6. Round | 11/11/2000 | AEK Athen | - | Panachaiki GE | 2:1 | ||||
| 7. Round | 18/11/2000 | Olympiakos Piraeus | - | Panachaiki GE | 3:0 | ||||
| 8. Round | 25/11/2000 | Panachaiki GE | - | PS Kalamata | 3:2 | ||||
| 9. Round | 02/12/2000 | PAS Giannina | - | Panachaiki GE | 1:1 | ||||
| 10. Round | 08/12/2000 | Panachaiki GE | - | Panionios GSS | 1:1 | |
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| 12. Round | 02/01/2001 | Panachaiki GE | - | OFI Heraklion | 2:1 | |
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| 13. Round | 06/01/2001 | Paniliakos Pyrgos | - | Panachaiki GE | 2:2 | |
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| 14. Round | 13/01/2001 | Panachaiki GE | - | Panathinaikos | 1:2 | |
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| 24. Round | 31/03/2001 | Panachaiki GE | - | PAS Giannina | 2:1 | ||||
| 26. Round | 19/04/2001 | Panachaiki GE | - | Aris Saloniki | 4:1 | ||||
| 29. Round | 19/05/2001 | Panathinaikos | - | Panachaiki GE | 4:0 |
Greece