| 1. Round | 12/02/2022 | FC Famalicão [Youth] | - | FC Vizela [Youth] | 2:2 | ||||
| 2. Round | 19/02/2022 | Leixões SC [Youth] | - | FC Famalicão [Youth] | 3:1 | ||||
| 3. Round | 27/02/2022 | FC Famalicão [Youth] | - | CD Tondela [Youth] | 1:0 | ||||
| 4. Round | 05/03/2022 | Paços de Ferreira [Youth] | - | FC Famalicão [Youth] | 2:0 |  |
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| 5. Round | 12/03/2022 | FC Famalicão [Youth] | - | CD Feirense [Youth] | 2:1 | ||||
| 6. Round | 19/03/2022 | Gil Vicente [Youth] | - | FC Famalicão [Youth] | 1:1 | ||||
| 7. Round | 03/04/2022 | FC Famalicão [Youth] | - | UD Oliveirense [Youth] | 2:0 | ||||
| 8. Round | 09/04/2022 | FC Vizela [Youth] | - | FC Famalicão [Youth] | 3:1 | ||||
| 9. Round | 16/04/2022 | FC Famalicão [Youth] | - | Leixões SC [Youth] | 1:1 |  |
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| 10. Round | 23/04/2022 | CD Tondela [Youth] | - | FC Famalicão [Youth] | 0:0 | ||||
| 11. Round | 30/04/2022 | FC Famalicão [Youth] | - | Paços de Ferreira [Youth] | 1:2 | ||||
| 13. Round | 14/05/2022 | FC Famalicão [Youth] | - | Gil Vicente [Youth] | 1:1 |
Portugal