| 1. Round | 24/07/2021 | Oud-Heverlee Leuven | - | SV Zulte Waregem | 1:1 | ||||
| 3. Round | 07/08/2021 | Sint-Truidense VV | - | SV Zulte Waregem | 1:3 | ||||
| 4. Round | 15/08/2021 | SV Zulte Waregem | - | Club Brugge KV | 0:4 | ||||
| 5. Round | 22/08/2021 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 | ||||
| 19. Round | 15/12/2021 | SV Zulte Waregem | - | Union Saint-Gilloise | 0:2 | ||||
| 20. Round | 18/12/2021 | SV Zulte Waregem | - | KV Mechelen | 3:2 |  |
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| 21. Round | 26/12/2021 | Standard Liège | - | SV Zulte Waregem | 0:1 | ||||
| 23. Round | 23/01/2022 | Cercle Brugge | - | SV Zulte Waregem | 3:1 | ||||
| 25. Round | 29/01/2022 | K Beerschot VA | - | SV Zulte Waregem | 3:3 | |
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| 26. Round | 06/02/2022 | KRC Genk | - | SV Zulte Waregem | 2:0 | ||||
| 22. Round | 09/02/2022 | SV Zulte Waregem | - | KV Oostende | 0:0 | ||||
| 27. Round | 12/02/2022 | SV Zulte Waregem | - | RSC Anderlecht | 1:2 | ||||
| 28. Round | 19/02/2022 | KV Kortrijk | - | SV Zulte Waregem | 5:0 | ||||
| 29. Round | 27/02/2022 | SV Zulte Waregem | - | RFC Seraing | 1:0 | ||||
| 30. Round | 06/03/2022 | KAA Gent | - | SV Zulte Waregem | 2:1 | ||||
| 31. Round | 12/03/2022 | SV Zulte Waregem | - | KAS Eupen | 3:0 |  |
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| 32. Round | 19/03/2022 | Royal Antwerp FC | - | SV Zulte Waregem | 1:0 |
Belgium