| Group A | 05/08/2015 | Santos Laguna | - | W Connection FC | 4:0 |  |
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| Group A | 26/08/2015 | Deportivo Saprissa | - | Santos Laguna | 2:1 |  |
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| Group A | 23/09/2015 | W Connection FC | - | Santos Laguna | 0:1 | ||||
| Group A | 21/10/2015 | Santos Laguna | - | Deportivo Saprissa | 6:1 | |
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| Quarter-finals | 02/03/2016 | Santos Laguna | - | Los Angeles Galaxy | 4:0 | |
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| Semi-finals | 17/03/2016 | Santos Laguna | - | CF América | 0:0 | ||||
| Semi-finals | 06/04/2016 | CF América | - | Santos Laguna | 1:0 aet | |
Cape Verde