| 5. Round | 15/08/2016 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 7. Round | 29/08/2016 | Santos Laguna | - | Club León | 1:0 | ||||
| 9. Round | 19/09/2016 | Santos Laguna | - | Pumas UNAM | 3:1 | ||||
| 10. Round | 22/09/2016 | CF Monterrey | - | Santos Laguna | 5:2 |  |
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| 11. Round | 26/09/2016 | Santos Laguna | - | Club Tijuana | 1:2 | ||||
| 12. Round | 01/10/2016 | Gallos Blancos | - | Santos Laguna | 1:1 | ||||
| 14. Round | 24/10/2016 | Santos Laguna | - | Atlas Guadalajara | 2:2 | ||||
| 15. Round | 30/10/2016 | CF América | - | Santos Laguna | 3:1 |  |
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| 16. Round | 07/11/2016 | Santos Laguna | - | Chiapas FC | 2:0 | ||||
| 17. Round | 20/11/2016 | Deportivo Toluca | - | Santos Laguna | 1:2 |
Cape Verde