| 4. Round | 12/09/2021 | Montpellier HSC [Youth] | - | OGC Nice [Youth] | 2:1 | ||||
| 6. Round | 26/09/2021 | Montpellier HSC [Youth] | - | FC Istres [Youth] | 2:0 | ||||
| 7. Round | 03/10/2021 | Pieve di Lota [Youth] | - | Montpellier HSC [Youth] | 0:2 | ||||
| 10. Round | 24/10/2021 | Montpellier HSC [Youth] | - | AC Ajaccio [Youth] | 2:2 | ||||
| 12. Round | 21/11/2021 | AS Saint-Étienne [Youth] | - | Montpellier HSC [Youth] | 0:0 | ||||
| 13. Round | 27/11/2021 | Montpellier HSC [Youth] | - | AS Béziers [Youth] | 1:0 | ||||
| 17. Round | 06/02/2022 | Montpellier HSC [Youth] | - | Toulouse FC [Youth] | 2:1 | ||||
| 19. Round | 06/03/2022 | Montpellier HSC [Youth] | - | Pieve di Lota [Youth] | 9:0 | ||||
| 20. Round | 13/03/2022 | AS Monaco [Youth] | - | Montpellier HSC [Youth] | 4:0 | ||||
| 23. Round | 10/04/2022 | Montpellier HSC [Youth] | - | Nîmes Olympique [Youth] | 3:0 |
France