| 18. Round | 02/08/2021 | FK Isloch Minsk | - | Shakhter Soligorsk | 0:1 | ||||
| 19. Round | 15/08/2021 | FK Smorgon | - | Shakhter Soligorsk | 2:2 | ||||
| 20. Round | 21/08/2021 | FK Slaviya Mozyr | - | Shakhter Soligorsk | 0:4 | ||||
| 21. Round | 27/08/2021 | Rukh Brest | - | Shakhter Soligorsk | 1:0 | ||||
| 23. Round | 18/09/2021 | BATE Borisov | - | Shakhter Soligorsk | 1:0 | ||||
| 24. Round | 26/09/2021 | Shakhter Soligorsk | - | Neman Grodno | 1:0 | ||||
| 26. Round | 17/10/2021 | Shakhter Soligorsk | - | Torpedo-BelAZ Zhodino | 3:1 | ||||
| 27. Round | 23/10/2021 | FK Vitebsk | - | Shakhter Soligorsk | 1:2 | ||||
| 16. Round | 31/10/2021 | FK Minsk | - | Shakhter Soligorsk | 0:3 | ||||
| 29. Round | 20/11/2021 | Dinamo Brest | - | Shakhter Soligorsk | 0:3 |  |
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| 30. Round | 28/11/2021 | Shakhter Soligorsk | - | FK Gomel | 0:1 |  |
Croatia