| 16. Round | 12/02/2022 | NK Solin | - | NK Kustošija | 2:1 | ||||
| 17. Round | 19/02/2022 | NK Kustošija | - | NK Croatia Zmijavci | 2:1 |  |
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| 18. Round | 26/02/2022 | NK Opatija | - | NK Kustošija | 2:1 | ||||
| 19. Round | 05/03/2022 | NK Kustošija | - | NK Varaždin | 0:2 | ||||
| 20. Round | 12/03/2022 | NK Rudeš | - | NK Kustošija | 2:0 | ||||
| 21. Round | 19/03/2022 | NK Kustošija | - | NK Jarun | 1:1 | ||||
| 22. Round | 01/04/2022 | NK Sesvete | - | NK Kustošija | 0:2 | ||||
| 23. Round | 09/04/2022 | NK Kustošija | - | NK Dugopolje | 4:2 |  |
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| 24. Round | 16/04/2022 | NK Dubrava | - | NK Kustošija | 1:2 | ||||
| 26. Round | 30/04/2022 | HNK Cibalia | - | NK Kustošija | 1:1 | ||||
| 27. Round | 07/05/2022 | NK Kustošija | - | NK Inter Zaprešić | 1:1 | ||||
| 28. Round | 16/05/2022 | NK Osijek II | - | NK Kustošija | 0:1 | ||||
| 29. Round | 22/05/2022 | NK BSK Bijelo Brdo | - | NK Kustošija | 2:3 | ||||
| 30. Round | 28/05/2022 | NK Kustošija | - | Dinamo Zagreb II | 3:2 |
Croatia